Clindamycin is an antibiotic that protects against a large group of bacteria. Although it does not kill the bacteria directly, it prevents the bacteria from multiplying in the event of a disease. This antibiotic is especially popular with bacteria that do not need oxygen as food. It also helps well with bone infections. This is because clindamycin easily turns into fat and bone marrow is largely made up of fat. Another use of clindamycin is the use on the skin in acne vulgaris, especially in adolescents.
Forms of clindamycin
This antibiotic has the advantage that it can not only be taken orally via the blood, but also uncomplicated. It is almost 100 percent from the stomach into the blood. Usually, the dosage consists of four receipts a day.
Clindamycin can be administered as a juice, as a disintegrating granule, as a tablet or as a capsule. In addition, it is available as a topical substance for application to the skin in the form of gel or solution. This helps especially with acne.
Dosage of the active ingredient
Most clindamycin is broken down via the liver and excreted mainly by the kidneys. Patients with severe hepatic or renal impairment should therefore adjust the dosage and take a smaller dose of medication, depending on the individual case.
The individual dose must be discussed with the attending physician and pharmacist.
Tips for taking
The clindamycin capsules should always be taken with sufficient fluid to prevent esophageal inflammation.
The clindamycin gel for application to the skin should be used only from the age of 12 years. It is generally not recommended for irritated or dry skin, purulent blemishes, rash or skin cancer.
What is the effect of clindamycin?
Clindamycin can generally help with infections of:
- Skin and soft tissues (acne)
- Bones and joints (osteomyelitis: inflammation of the bone marrow)
- Tooth and jaw
- Ear, nose and throat area
- Female genitalia
In addition, clindamycin is an important reserve antibiotic for people who have an allergy to penicillin (the most common antibiotic) and other related antibiotics. It can then, for example, help against streptococci, the causative agents of purulent tonsillitis.
Side effects of clindamycin
Clindamycin belongs to the antibiotics, which can have a strong effect on the natural colonization of the intestine, the so-called intestinal flora. Therefore, side effects often occur when taking clindamycin. These include gastrointestinal complaints such as abdominal pain, nausea, vomiting and diarrhea.
In some cases, the antibiotic can cause a rash allergy or allergic shock. Therefore, patients with a history of allergies need to be especially careful. In addition, the contraceptive effect of oral contraceptives by clindamycin may be limited.
Pseudomembranous colitis as a side effect
In the worst case, pseudomembranous colitis may be a side effect of taking clindamycin. Pseudomembranous colitis is sometimes a life-threatening intestinal inflammation caused by the bacterium Clostridium difficile.
This can colonize the intestine if the natural intestinal flora is damaged. This may in turn be in the form of fever, severe abdominal pain and diarrhea.
Contraindications for Clindamycin
Absolute contraindications to the use of clindamycin are hypersensitivity to the drug. In addition, inflammatory bowel diseases, such as ulcerative colitis, are contraindications due to the side effects mentioned.
In addition, clindamycin may enhance the effect of muscle relaxants during surgery, and caution should be exercised in surgery and generally in patients with Parkinson's or myasthenia gravis (and other neuromuscular transmission disorders).
Use in pregnancy?
Since there are only a few study results on the use of clindamycin in pregnancy, antibiotic therapy with clindamycin during pregnancy is not recommended. Likewise during lactation, as clindamycin passes into breast milk. In individual cases, a risk-benefit analysis should be carried out individually with the attending physician.